Are you tired of OneDrive icons polluting your file explorer tree view? If you don’t use OneDrive, then here are two handy functions that hide and show the OneDrive icons in File Explorer:

function Disable-OneDrive
{
  $regkey1 = 'Registry::HKEY_CLASSES_ROOT\CLSID\{018D5C66-4533-4307-9B53-224DE2ED1FE6}'
  $regkey2 = 'Registry::HKEY_CLASSES_ROOT\Wow6432Node\CLSID\{018D5C66-4533-4307-9B53-224DE2ED1FE6}'
    Set-ItemProperty -Path $regkey1, $regkey2 -Name System.IsPinnedToNameSpaceTree -Value 0
}


function Enable-OneDrive
{
    $regkey1 = 'Registry::HKEY_CLASSES_ROOT\CLSID\{018D5C66-4533-4307-9B53-224DE2ED1FE6}'
    $regkey2 = 'Registry::HKEY_CLASSES_ROOT\Wow6432Node\CLSID\{018D5C66-4533-4307-9B53-224DE2ED1FE6}'
    Set-ItemProperty -Path $regkey1, $regkey2 -Name System.IsPinnedToNameSpaceTree -Value 1
}

Source: Hide OneDrive from File Explorer – Power Tips – PowerTips – IDERA Community